Formulation and Assessment of Liposomes Entrapped Natural Substance for Mammary Cancer Treatment

Breast/mammary cancer is the most common in women due to abandoned breast tissue growth. Many therapies and treatments are available for treatment. However, each therapy or treatment has its side effect. The natural compound uncovered a significant influence on development of contemporary with reduced effects. But it lags behind race lesser bioavailability indecorous delivered dosage form. In this research efforts made develop novel targeted dose delivery system cancer. cell shown higher expression HIF-1α, TOP-II α, Proteine Kinase C, MMP-2 receptors. By reviewing literature followed by molecular modeling these receptors, seven compounds were identified which have effect above receptors: sesamin, aloe-emodin, gallic acid, catechin, Butein, 6-gingerol, curcumin, respectively. Hence Liposomes prepared different formulations entrap all active compounds. Then formulated liposomes characterized, their stabilities also evaluated 60 days at room temperature 2-8 °C. Among formulations, GCDCA (1.8 mM), lecithin (62.12 cholesterol (25.88 mM) proven be stable, robust, effective formulation using MCF-7 line.